Equipment and expertise (including bioinformatics) for small- and large-scale DNA and RNA analysis. Applications that are covered are: Targeted and genome-wide SNP and mutation detection and discovery (SNPs, in/dels, copy number variation, structural variation), ChIP-Seq, RNA-seq, chromatine organization, small RNA analysis.

AB3730XL capillary sequencers (3) PCR capacity for >25,000 simultaneous reactions (PCR, sequencing) Liquid handling robots with 8, 96 and 384-channel formats AB/SOLiD sequencers (3) with a capacity of generating >50Gbp per run IonTorrent Personal Genome Machine (1) Roche/454 GS-FLX sequencer (1) Illumina iScan suited for Infinium HD SureScan High-Resolution Agilent DNA microarray scanner

ecuppen@umcutrecht.nl

e.cuppen@hubrecht.eu